Arsenal will travel to Leicester City in the Carabao Cup third round, while Liverpool, Tottenham, and Manchester United all face potentially tricky away ties after the draws for the second and third rounds were made on Sunday.
Jürgen Klopp’s side will face either Bradford or Lincoln City, while Tottenham could face a short trip to Leyton Orient – or a much longer journey to Plymouth, who knocked QPR out on Saturday.
Manchester United will visit either Luton or Reading, while Chelsea will welcome the winner of Middlesbrough v Barnsley in round three.
Manchester City, who have won the trophy three years in a row, will host Bournemouth or Crystal Palace, who meet in one of the headline ties in the second round draw’s southern half.
West Ham will host Charlton, the Premier League returnees Fulham takes on Ipswich, and Brighton face Portsmouth in a south-coast derby.
In the northern section, the EFL newcomers Harrogate Town have earned a tie at West Brom after beating Tranmere on penalties.
Aston Villa faces a short but testing trip to Burton Albion, Salford City go to Goodison Park to play Everton, and Burnley take on Sheffield United in an all-Premier League tie.
On Sunday, Brentford beat Wycombe on penalties in the first match at their new stadium to set up a second-round trip to Southampton. The Bees defender Ethan Pinnock headed in the first goal at the Brentford Community Stadium but his poor pass allowed Daryl Horgan to equalize for the Championship newcomers.
In the shootout, Luke Daniels saved Scott Kashket’s spot-kick to give Brentford the advantage, and Marcus Forss scored to earn a 4-2 win on penalties.
Here’s the second round, followed by the prospective third round, fixtures in full:
Round Two – South Region
West Ham United vs Charlton Athletic
Ipswich Town vs Fulham
Oxford United vs Watford
Bournemouth vs Crystal Palace
Leyton Orient vs Plymouth Argyle
Southampton vs Brentford
Bristol City vs Northampton Town
Reading vs Luton Town
Millwall vs Cheltenham Town
Brighton and Hove Albion vs Portsmouth
Newport County vs Cambridge United
Gillingham vs Coventry City
Round Two – North Region
Burnley vs Sheffield United
Burton Albion vs Aston Villa
Bradford City vs Lincoln City
Leeds United vs Hull City
Everton vs Salford City
Wolverhampton Wanderers vs Stoke City
Rochdale vs Sheffield Wednesday
West Bromwich Albion vs Harrogate Town
Middlesbrough vs Barnsley
Derby County vs Preston North End
Newcastle United vs Blackburn Rovers
Morecambe vs Oldham Athletic
Fleetwood Town vs Port Vale
Round Three fixtures
Bradford or Lincoln City vs Liverpool
Bristol City or Northampton Town vs Burton Albion or Aston Villa
Morecambe or Oldham Athletic vs Newcastle United or Blackburn Rovers
Reading or Luton Town vs Manchester United
Derby County or Preston vs Brighton or Portsmouth
Ipswich or Fulham vs Rochdale or Sheffield Wednesday
Manchester City vs Bournemouth or Crystal Palace
Millwall or Cheltenham vs Burnley or Sheffield United
Chelsea vs Middlesbrough or Barnsley
Wolves or Stoke City vs Gillingham or Coventry City
Leicester City vs Arsenal
West Brom or Harrogate vs Southampton or Brentford
Newport County or Cambridge United vs Oxford United or Watford
Fleetwood or Port Vale vs Everton or Salford City
Leyton Orient or Plymouth vs Tottenham Hotspur
West Ham or Charlton vs Leeds United or Hull City